Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 7/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.49 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.40 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.39 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13076725 | 0.90 | GRIN1 (0.50) | GRIN1GRIN2BEPHX2SMN1; SMN2S1PR3 | |
| SCHEMBL13076485 | 0.90 | GRIN1 (0.50) | GRIN1GRIN2BEPHX2SMN1; SMN2LMNA | |
| SCHEMBL3803815 | 0.88 | EPHX2 (0.49) | EPHX2LIPG | |
| SCHEMBL13076473 | 0.82 | EPHX2 (0.53) | EPHX2 | |
| SCHEMBL13075758 | 0.82 | MAPT (0.45) | GRIN1GRIN2BEPHX2 | |
| SCHEMBL13075698 | 0.82 | EPHX2 (0.45) | GRIN1GRIN2BEPHX2 | |
| SCHEMBL13076533 | 0.81 | MAPT (0.44) | GRIN1GRIN2BEPHX2HTTS1PR3 | |
| SCHEMBL3716663 | 0.78 | ALDH1A1 (0.48) | GRIN1GRIN2BEPHX2 | |
| SCHEMBL3722318 | 0.78 | CD274 (0.46) | LIPG | |
| SCHEMBL3724166 | 0.77 | ALDH1A1 (0.46) | EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129848-A2 | 2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXAMIDES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-11-11 | — | — | WO | disclosed |