Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.43 |
| ▸ | NPC1 | O15118 | 7/20 | 0.43 |
| ▸ | TP53 | P04637 | 7/20 | 0.43 |
| ▸ | PKM | P14618 | 7/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 5/20 | 0.42 |
| ▸ | PTGES | O14684 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13076262 | 0.86 | RAB9A (0.45) | RAB9ANPC1TP53SMN1; SMN2TSHR | |
| SCHEMBL3790517 | 0.85 | PTGES (0.54) | RAB9ANPC1TP53PKMSMN1; SMN2 | |
| SCHEMBL13076255 | 0.85 | NPC1 (0.46) | RAB9ANPC1TP53SMN1; SMN2MAPT | |
| SCHEMBL13076382 | 0.84 | HTT (0.42) | RAB9ANPC1MAPTTSHRL3MBTL1 | |
| SCHEMBL13076234 | 0.83 | PTGES (0.61) | RAB9ANPC1TP53PKMSMN1; SMN2 | |
| SCHEMBL3795498 | 0.83 | PTGES (0.45) | RAB9ANPC1TP53PKMSMN1; SMN2 | |
| SCHEMBL13076380 | 0.82 | PTGES (0.35) | RAB9ANPC1TP53SMN1; SMN2TSHR | |
| SCHEMBL13076263 | 0.82 | NPC1 (0.35) | RAB9ANPC1TP53SMN1; SMN2MAPT | |
| SCHEMBL13076244 | 0.82 | NPC1 (0.43) | RAB9ANPC1TP53SMN1; SMN2TSHR | |
| SCHEMBL13076253 | 0.82 | NPC1 (0.38) | RAB9ANPC1TP53SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |