Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 6/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13076263 | 0.90 | NPC1 (0.35) | RAB9ANPC1CASP3SENP8SENP7 | |
| SCHEMBL13076380 | 0.86 | PTGES (0.35) | RAB9ANPC1CASP3SENP8SENP7 | |
| SCHEMBL3802070 | 0.86 | PTGES (0.49) | HTTGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL13076233 | 0.84 | RAB9A (0.43) | RAB9ANPC1CASP3SENP8SENP7 | |
| SCHEMBL13076262 | 0.80 | RAB9A (0.45) | RAB9ANPC1CASP3SENP8SENP7 | |
| SCHEMBL13076244 | 0.80 | NPC1 (0.43) | HTTRAB9ANPC1CASP3SENP7 | |
| SCHEMBL13076236 | 0.80 | NPC1 (0.45) | RAB9ANPC1CASP3SENP7SENP6 | |
| SCHEMBL13076255 | 0.80 | NPC1 (0.46) | HTTRAB9ANPC1L3MBTL1PTGES | |
| SCHEMBL13076379 | 0.79 | GRM5 (0.45) | RAB9ANPC1ALDH1A1MAPK1CHRNB2 | |
| SCHEMBL13076381 | 0.78 | HSD11B1 (0.34) | RAB9ANPC1CASP3SENP8SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |