Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 10/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | PKM | P14618 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13076234 | 0.87 | PTGES (0.61) | PTGESMAPK14RAB9ANPC1TP53 | |
| SCHEMBL3790517 | 0.85 | PTGES (0.54) | PTGESRAB9ANPC1TP53SMN1; SMN2 | |
| SCHEMBL3790934 | 0.84 | RAB9A (0.50) | PTGESMAPK14RAB9ANPC1TP53 | |
| SCHEMBL13076233 | 0.83 | RAB9A (0.43) | PTGESRAB9ANPC1TP53SMN1; SMN2 | |
| SCHEMBL3800580 | 0.82 | PTGES (0.50) | PTGESMAPK14JAK2 | |
| SCHEMBL3790737 | 0.78 | PTGES (0.49) | PTGESMAPK14RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3793065 | 0.78 | PTGES (0.47) | PTGESMAPK14JAK2 | |
| SCHEMBL3805843 | 0.78 | PTGES (0.46) | PTGESMAPK14JAK2 | |
| SCHEMBL3795197 | 0.77 | PTGES (0.47) | PTGESMAPK14JAK2 | |
| SCHEMBL13075627 | 0.77 | PTGES (0.47) | PTGESMAPK14RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | claimed |
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |