Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 7/20 | 0.70 |
| ▸ | MAPT | P10636 | 7/20 | 0.70 |
| ▸ | SNCA | P37840 | 7/20 | 0.70 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.57 |
| ▸ | CDK1 | P06493 | 1/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.57 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.57 |
| ▸ | CCR6 | P51684 | 1/20 | 0.57 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.57 |
| ▸ | METAP1 | P53582 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.52 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6835454 | 0.83 | MEN1 (0.73) | CCNB2CDK1HSP90AA1CCNB1CCR6 | |
| SCHEMBL6857929 | 0.83 | MEN1 (0.73) | CCNB2CDK1HSP90AA1CCNB1CCR6 | |
| SCHEMBL3762229 | 0.83 | MAPT (1.00) | APPMAPTSNCAMETAP1MEN1 | |
| SCHEMBL13080908 | 0.81 | MAPT (0.56) | APPMAPTSNCACCNB2CDK1 | |
| SCHEMBL13081090 | 0.80 | APP (0.74) | APPMAPTSNCAMETAP1MEN1 | |
| SCHEMBL3798471 | 0.80 | APP (0.74) | APPMAPTSNCAMETAP1MEN1 | |
| SCHEMBL3798469 | 0.80 | APP (0.74) | APPMAPTSNCAMETAP1MEN1 | |
| SCHEMBL1239938 | 0.78 | MAPT (0.50) | APPMAPTSNCAMETAP1MEN1 | |
| SCHEMBL1239940 | 0.78 | MAPT (0.50) | APPMAPTSNCAMETAP1MEN1 | |
| SCHEMBL16160384 | 0.75 | MAPT (0.74) | APPMAPTSNCAMETAP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298376-A1 | USE OF NOVEL NEUROPROTECTIVE 3-SUBSTITUTED INDOLONE COMPOSITIONS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2010-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298376-A1 | USE OF NOVEL NEUROPROTECTIVE 3-SUBSTITUTED INDOLONE COMPOSITIONS | NLN, HTT, PARK7 | APP 31/4885MAPT 59/4885SNCA 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.