Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 1.00 |
| ▸ | APP | P05067 | 6/20 | 1.00 |
| ▸ | SNCA | P37840 | 6/20 | 1.00 |
| ▸ | METAP1 | P53582 | 2/20 | 0.66 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | CMA1 | P23946 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16160384 | 0.85 | MAPT (0.74) | MAPTAPPSNCAMETAP1KDM4E | |
| SCHEMBL25837037 | 0.83 | APP (1.00) | MAPTAPPSNCAMETAP1EPHX2 | |
| SCHEMBL30482935 | 0.83 | APP (1.00) | MAPTAPPSNCAMETAP1EPHX2 | |
| SCHEMBL21751777 | 0.83 | APP (1.00) | MAPTAPPSNCAMETAP1EPHX2 | |
| SCHEMBL13081135 | 0.83 | APP (0.70) | MAPTAPPSNCAMETAP1MEN1 | |
| SCHEMBL247891 | 0.80 | PDGFRB (0.76) | MAPTAPPSNCAALDH1A1PKM | |
| SCHEMBL29875506 | 0.80 | PDGFRB (0.76) | MAPTAPPSNCAALDH1A1PKM | |
| SCHEMBL1301398 | 0.80 | PDGFRB (0.76) | MAPTAPPSNCAALDH1A1PKM | |
| SCHEMBL247890 | 0.80 | PDGFRB (0.76) | MAPTAPPSNCAALDH1A1PKM | |
| SCHEMBL11598589 | 0.80 | METAP1 (1.00) | MAPTAPPSNCAMETAP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090264494-A1 | USE OF NEUROPROTECTIVE 3-SUBSTITUTED INDOLONE COMPOSITIONS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2009-10-22 | — | — | US | claimed |
| US-20100298376-A1 | USE OF NOVEL NEUROPROTECTIVE 3-SUBSTITUTED INDOLONE COMPOSITIONS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2010-11-25 | — | — | US | disclosed |
| US-20090264494-A1 | USE OF NEUROPROTECTIVE 3-SUBSTITUTED INDOLONE COMPOSITIONS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298376-A1 | USE OF NOVEL NEUROPROTECTIVE 3-SUBSTITUTED INDOLONE COMPOSITIONS | NLN, HTT, PARK7 | MAPT 59/4885APP 31/4885SNCA 4/4885 |
| US-20090264494-A1 | USE OF NEUROPROTECTIVE 3-SUBSTITUTED INDOLONE COMPOSITIONS | NLN, BDNF, HTT | MAPT 43/4885APP 38/4885SNCA 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.