Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 1.00 |
| ▸ | RAB9A | P51151 | 10/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.75 |
| ▸ | POLB | P06746 | 2/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | HPGD | P15428 | 2/20 | 0.72 |
| ▸ | GAA | P10253 | 1/20 | 0.72 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.72 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.72 |
| ▸ | RELA | Q04206 | 1/20 | 0.72 |
| ▸ | PKM | P14618 | 1/20 | 0.71 |
| ▸ | ATM | Q13315 | 2/20 | 0.70 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.68 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.68 |
| ▸ | TNF | P01375 | 1/20 | 0.66 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.66 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9504780 | 0.89 | NPC1 (0.80) | NPC1RAB9ASMN1; SMN2MAPTHPGD | |
| SCHEMBL13431307 | 0.89 | NPC1 (0.80) | NPC1RAB9ASMN1; SMN2MAPTHPGD | |
| SCHEMBL13089346 | 0.83 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2MAPTPOLB | |
| SCHEMBL15307624 | 0.81 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL4930218 | 0.78 | SMN1; SMN2 (0.65) | NPC1RAB9ASMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL4930224 | 0.78 | SMN1; SMN2 (0.65) | NPC1RAB9ASMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL13171349 | 0.78 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL3410035 | 0.77 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL3410029 | 0.77 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL13427341 | 0.77 | PKM (0.63) | NPC1RAB9ASMN1; SMN2MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9045442-B2 | Antibacterial compounds and methods of using same | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2015-06-02 | — | — | US | disclosed |
| US-9045442-B2 | Antibacterial compounds and methods of using same | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2015-06-02 | — | — | US | disclosed |
| US-20100261673-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS OF USING SAME | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2010-10-14 | — | — | US | disclosed |
| US-20100261673-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS OF USING SAME | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2010-10-14 | — | — | US | disclosed |
| WO-2009082398-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS OF USING SAME | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2009-07-02 | — | — | WO | disclosed |
| WO-2009041972-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS OF USING SAME | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2009-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261673-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS OF USING SAME | SPOUT1, MRPL21, NPEPPS | NPC1 4451/4885RAB9A 3902/4885SMN1; SMN2 3649/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.