Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 2/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.33 |
| ▸ | CCR9 | P51686 | 6/20 | 0.33 |
| ▸ | CKS1B | P61024 | 1/20 | 0.33 |
| ▸ | SKP1 | P63208 | 1/20 | 0.33 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5220970 | 0.85 | NOD2 (0.40) | GABRG2GABRB3GABRA5KMT2AMEN1 | |
| SCHEMBL13204737 | 0.81 | GABRG2 (0.34) | GABRG2GABRB3GABRA5AURKACDK2 | |
| SCHEMBL18416826 | 0.80 | FAAH (0.36) | GABRG2GABRB3GABRA5AURKACDK2 | |
| SCHEMBL2877718 | 0.78 | SRD5A2 (0.49) | KMT2AMEN1HPGDHSD17B10 | |
| SCHEMBL4549881 | 0.78 | AURKA (0.40) | GABRG2GABRB3GABRA5AURKACDK2 | |
| SCHEMBL2875438 | 0.74 | NOD2 (0.37) | GABRG2GABRB3GABRA5NR1H2KMT2A | |
| SCHEMBL5223580 | 0.73 | HPGD (0.38) | GABRG2GABRB3GABRA5NR1H2HPGD | |
| SCHEMBL2875278 | 0.73 | HRH3 (0.42) | — | |
| SCHEMBL23926520 | 0.73 | CDK2 (0.48) | GABRG2GABRB3GABRA5AURKACDK2 | |
| SCHEMBL22130269 | 0.72 | GABRG2 (0.36) | GABRG2GABRB3GABRA5AURKACDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966199-B1 | AZAINDOLE-2-CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-10-20 | — | — | EP | disclosed |
| US-7786109-B2 | Tricyclic amide derivatives as modulators of H3 receptors | HOFFMANN-LA ROCHE INC. (US) | 2010-08-31 | — | — | US | disclosed |
| US-7622466-B2 | Azaindole-2-carboxamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2009-11-24 | — | — | US | disclosed |
| US-7579351-B2 | Tricyclic amide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-08-25 | — | — | US | disclosed |
| US-20090156583-A1 | Tricyclic Amide Derivatives | NETTEKOVEN MATTHIAS | 2009-06-18 | — | — | US | disclosed |
| US-20090005379-A1 | Azaindole-2-Carboxamide Derivatives | HOFFMANN-LA ROCHE, INC. | 2009-01-01 | — | — | US | disclosed |
| US-20070135416-A1 | Tricyclic amide derivatives | HOFFMANN-LA ROCHE INC. | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156583-A1 | Tricyclic Amide Derivatives | HRH4, HRH3, HCAR1 | GABRG2 627/4885GABRB3 513/4885GABRA5 332/4885 |
| US-20070135416-A1 | Tricyclic amide derivatives | HRH4, HRH3, HCAR1 | GABRG2 627/4885GABRB3 513/4885GABRA5 332/4885 |
| US-20090005379-A1 | Azaindole-2-Carboxamide Derivatives | HRH3, HRH4, H1-5 | GABRG2 750/4885GABRB3 379/4885GABRA5 172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.