Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | FER | P16591 | 1/20 | 0.44 |
| ▸ | LTK | P29376 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8136244 | 0.88 | MEN1 (0.54) | MEN1KMT2AMAPTL3MBTL1POLB | |
| SCHEMBL19745771 | 0.80 | ALOX5 (0.59) | MEN1KMT2AMAPTL3MBTL1POLB | |
| SCHEMBL380110 | 0.78 | ALOX5 (0.61) | MEN1KMT2AMAPTL3MBTL1POLB | |
| SCHEMBL21764489 | 0.72 | MAPK1 (0.44) | ALDH1A1KDM4ETDP1MAOAMAOB | |
| SCHEMBL18516202 | 0.72 | MAPK1 (0.44) | ALDH1A1KDM4ETDP1MAOAMAOB | |
| SCHEMBL3409888 | 0.72 | AHR (0.49) | MEN1KMT2AMAPTL3MBTL1POLB | |
| SCHEMBL5357237 | 0.72 | MAPT (0.45) | MEN1KMT2AMAPTL3MBTL1POLB | |
| SCHEMBL8134709 | 0.72 | MAPT (0.49) | MEN1KMT2AMAPTL3MBTL1POLB | |
| SCHEMBL23499520 | 0.72 | PDGFRA (0.36) | MEN1KMT2AMAPTL3MBTL1POLB | |
| Hydrochloric Acid SCHEMBL5362202 | 0.71 | MAPT (0.44) | MEN1KMT2AMAPTL3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461145-B2 | Dibenzoazepine and dibenzooxazepine TRPA1 agonists | JANSSEN PHARMACEUTICA NV (BE) | 2013-06-11 | — | — | US | disclosed |
| US-8461145-B2 | Dibenzoazepine and dibenzooxazepine TRPA1 agonists | JANSSEN PHARMACEUTICA NV (BE) | 2013-06-11 | — | — | US | disclosed |
| US-20100273773-A1 | DIBENZOAZEPINE AND DIBENZOOXAZEPINE TRPA1 AGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | US | disclosed |
| US-20100273773-A1 | DIBENZOAZEPINE AND DIBENZOOXAZEPINE TRPA1 AGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | US | disclosed |
| WO-2009071631-A2 | DIBENZOAZEPINE AND DIBENZOOXAZEPINE TRPA1 AGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2009-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100273773-A1 | DIBENZOAZEPINE AND DIBENZOOXAZEPINE TRPA1 AGONISTS | TRPA1, TRPV1, TRPV2 | MEN1 4772/4885KMT2A 4016/4885MAPT 1080/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.