Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PTPRC | P08575 | 1/20 | 0.40 |
| ▸ | S100A4 | P26447 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30309507 | 1.00 | ALDH1A1 (0.52) | ALDH1A1HIF1AHPGDNPSR1MCOLN3 | |
| SCHEMBL27889278 | 0.86 | ALDH1A1 (0.49) | ALDH1A1HIF1AHPGDNPSR1MCOLN3 | |
| SCHEMBL31506366 | 0.85 | ALDH1A1 (0.56) | ALDH1A1HIF1AHPGDNPSR1MCOLN3 | |
| SCHEMBL3641932 | 0.85 | ALDH1A1 (0.56) | ALDH1A1HIF1AHPGDNPSR1MCOLN3 | |
| SCHEMBL15076678 | 0.83 | ALDH1A1 (0.53) | ALDH1A1HIF1AHPGDTSHRTDP1 | |
| SCHEMBL11526155 | 0.82 | ALDH1A1 (0.51) | ALDH1A1HPGDNPSR1MCOLN3TSHR | |
| SCHEMBL16216330 | 0.82 | AKR1C3 (0.52) | ALDH1A1HIF1AKMT2AGAALMNA | |
| SCHEMBL16207559 | 0.82 | AKR1C3 (0.52) | ALDH1A1HIF1AKMT2AGAALMNA | |
| SCHEMBL6098967 | 0.81 | ALDH1A1 (0.47) | ALDH1A1HIF1ATSHRTDP1CYP3A4 | |
| SCHEMBL9735630 | 0.79 | PDK1 (0.55) | ALDH1A1HIF1AHPGDNPSR1MCOLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210087188-A1 | 5,6-DIHYDRO-1 1H-INDOLO{2,3-B}QUINOLIN- 11-ONE COMPOUNDS AS ALK INHIBITORS | The Regents oof the University of Michigan (US) | 2021-03-25 | — | — | US | disclosed |
| CN-110294750-A | 5,6- dihydro -11H- indoles as ALK inhibitor simultaneously [2,3-B] quinoline -11- ketone compound | 密执安州立大学董事会 | 2019-10-01 | — | — | CN | disclosed |
| WO-2019179482-A1 | 5, 6-DIHYDRO-11H-INDOLO [2, 3-B] QUINOLIN-11-ONE COMPOUNDS AS ALK INHIBITORS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2019-09-26 | — | — | WO | disclosed |
| US-8778874-B2 | Glycopeptide antibiotic monomer derivatives | NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (JP) | 2014-07-15 | — | — | US | disclosed |
| US-8530646-B2 | Oxazolidinone derivative having 7-membered hetero ring | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2013-09-10 | — | — | US | disclosed |
| US-20100256355-A1 | OXAZOLIDINONE DERIVATIVE HAVING 7-MEMBERED HETERO RING | Research Foundation ITSUU Laboratory and Shionogi & Co., Ltd. | 2010-10-07 | — | — | US | disclosed |
| US-20080097078-A1 | Antibacterial activity against vancomycin-resistant bacteria | SHIONOGI & CO., LTD. (JP) | 2008-04-24 | — | — | US | disclosed |
| US-20080097078-A1 | Antibacterial activity against vancomycin-resistant bacteria | SHIONOGI & CO., LTD. (JP) | 2008-04-24 | — | — | US | disclosed |
| US-7329663-B2 | Substituted-triazolopyrimidines as anticancer agents | WYETH (US) | 2008-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210087188-A1 | 5,6-DIHYDRO-1 1H-INDOLO{2,3-B}QUINOLIN- 11-ONE COMPOUNDS AS ALK INHIBITORS | ALK, KRAS, ABL1 | ALDH1A1 108/4885HIF1A 2877/4885HPGD 4430/4885 |
| US-20080097078-A1 | Antibacterial activity against vancomycin-resistant bacteria | CSGALNACT1, MON2, NR2C2 | ALDH1A1 2289/4885HIF1A 1114/4885HPGD 3950/4885 |
| US-20100256355-A1 | OXAZOLIDINONE DERIVATIVE HAVING 7-MEMBERED HETERO RING | NR0B2, NR0B1, NR2C2 | ALDH1A1 2721/4885HIF1A 2765/4885HPGD 3576/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.