Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | OGA | O60502 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14539600 | 0.77 | PDE4A (0.37) | MAPTKDM4EOGACYP2C19ALDH1A1 | |
| SCHEMBL13110284 | 0.74 | OGA (0.36) | OGACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL13110285 | 0.74 | OGA (0.34) | MAPTKDM4EOGACYP2C9CYP2C19 | |
| SCHEMBL6928335 | 0.70 | OGA (0.38) | KDM4EOGACYP2C9CYP2C19 | |
| SCHEMBL6927099 | 0.70 | OGA (0.38) | KDM4EOGACYP2C9CYP2C19 | |
| SCHEMBL6928345 | 0.70 | OGA (0.38) | KDM4EOGACYP2C9CYP2C19 | |
| SCHEMBL6927105 | 0.70 | OGA (0.38) | KDM4EOGACYP2C9CYP2C19 | |
| SCHEMBL6927102 | 0.70 | OGA (0.38) | KDM4EOGACYP2C9CYP2C19 | |
| SCHEMBL14539583 | 0.69 | PSEN1 (0.51) | ALDH1A1HTT | |
| SCHEMBL5656187 | 0.69 | PSEN1 (0.55) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820699-B2 | Cyclic amines | HOFFMANN-LA ROCHE INC. (US) | 2010-10-26 | — | — | US | disclosed |