Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGA | O60502 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.30 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13110286 | 0.86 | GAA (0.33) | ALDH1A1GAAHTTMAPTCAPN9 | |
| SCHEMBL14539600 | 0.78 | PDE4A (0.37) | OGACYP2C19ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL10137516 | 0.78 | MAPT (0.34) | ALDH1A1GAASMN1; SMN2MAPT | |
| SCHEMBL13110289 | 0.78 | PPM1B (0.37) | ALDH1A1MAPT | |
| SCHEMBL14348076 | 0.78 | MAPT (0.34) | ALDH1A1GAAMAPTCAPN9 | |
| SCHEMBL12993310 | 0.78 | CPB1 (0.49) | ALDH1A1GAA | |
| SCHEMBL13110288 | 0.74 | MAPT (0.37) | OGACYP2C9CYP2C19ALDH1A1HTT | |
| SCHEMBL14651109 | 0.74 | ALDH1A1 (0.43) | ALDH1A1GAASMN1; SMN2HTTKDM4E | |
| SCHEMBL14348069 | 0.74 | ALDH1A1 (0.43) | ALDH1A1GAASMN1; SMN2HTTKDM4E | |
| SCHEMBL14651075 | 0.74 | ALDH1A1 (0.43) | ALDH1A1GAASMN1; SMN2HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820699-B2 | Cyclic amines | HOFFMANN-LA ROCHE INC. (US) | 2010-10-26 | — | — | US | disclosed |