Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | GALR2 | O43603 | 3/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13110688 | 0.86 | MAPT (0.58) | MAPTTP53HPGDALOX15TSHR | |
| SCHEMBL13288470 | 0.83 | ROCK1 (0.82) | MAPTTP53HPGDALOX15TSHR | |
| SCHEMBL13110690 | 0.81 | AGPAT2 (0.57) | MAPTTP53HPGDALOX15TSHR | |
| SCHEMBL5743457 | 0.78 | ACP1 (0.54) | MAPTTP53HPGDALOX15TSHR | |
| SCHEMBL5743353 | 0.78 | RAB9A (0.52) | MAPTTP53HPGDALOX15TSHR | |
| SCHEMBL3450227 | 0.78 | MAPT (0.57) | MAPTTP53HPGDALOX15TSHR | |
| SCHEMBL15757020 | 0.78 | ALDH1A1 (0.56) | MAPTTP53HPGDALOX15TSHR | |
| SCHEMBL12727986 | 0.77 | MAPT (0.65) | MAPTTP53HPGDALOX15TSHR | |
| SCHEMBL13110691 | 0.77 | AGPAT2 (0.55) | MAPTTP53HPGDALOX15TSHR | |
| SCHEMBL13110692 | 0.77 | AGPAT2 (0.58) | MAPTTP53HPGDALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820654-B2 | Pyrimidine compounds, process for their preparation and compositions containing them | DR. REDDY'S LABORATORIES LTD. (IN) | 2010-10-26 | — | — | US | disclosed |
| US-7820654-B2 | Pyrimidine compounds, process for their preparation and compositions containing them | DR. REDDY'S LABORATORIES LTD. (IN) | 2010-10-26 | — | — | US | disclosed |