Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.40 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19123620 | 0.90 | SMN1; SMN2 (0.47) | SMN1; SMN2AKR1C3AKR1C2AKR1C1AKR1C4 | |
| SCHEMBL13315468 | 0.79 | SMN1; SMN2 (0.58) | SMN1; SMN2AKR1C3AKR1C2AKR1C1AKR1C4 | |
| SCHEMBL14390906 | 0.76 | ALOX15 (0.38) | SMN1; SMN2HPGDKMT2AMEN1MAPT | |
| SCHEMBL6468002 | 0.75 | KDM4E (0.42) | SMN1; SMN2HPGDHSD17B10KDM4EGLA | |
| SCHEMBL4640445 | 0.75 | SMN1; SMN2 (0.49) | SMN1; SMN2AKR1C3AKR1C2AKR1C1AKR1C4 | |
| SCHEMBL984633 | 0.73 | SMN1; SMN2 (0.44) | SMN1; SMN2HPGDHSD17B10KDM4EKMT2A | |
| SCHEMBL19123318 | 0.73 | AKR1C3 (0.44) | SMN1; SMN2AKR1C3AKR1C2AKR1C1AKR1C4 | |
| SCHEMBL30995642 | 0.73 | AKR1C3 (0.44) | SMN1; SMN2AKR1C3AKR1C2AKR1C1AKR1C4 | |
| SCHEMBL11732758 | 0.73 | AKR1C3 (0.44) | SMN1; SMN2AKR1C3AKR1C2AKR1C1AKR1C4 | |
| SCHEMBL31204901 | 0.73 | LMNA (0.35) | SMN1; SMN2ALDH1A1MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537091-B1 | NOVEL 2-ARYLTHIAZOLE COMPOUNDS AS PPARALPHA AND PPARGAMMA AGONISTS | HOFFMANN LA ROCHE (CH) | 2010-10-06 | — | — | EP | disclosed |
| EP-1572203-B1 | SUBSTITUTED 4-ALKOXYOXAZOL DERIVATIVES AS PPAR AGONISTS | HOFFMANN LA ROCHE (CH) | 2007-11-07 | — | — | EP | disclosed |