Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 4/20 | 0.45 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13213459 | 0.86 | TDP1 (0.36) | PDCD1CD274TDP1THRBRAD52 | |
| SCHEMBL2907137 | 0.83 | CD274 (0.38) | PDCD1CD274CYP4F2CYP4A11S1PR1 | |
| SCHEMBL13117624 | 0.83 | CD274 (0.40) | PDCD1CD274CYP4F2CYP4A11RAD52 | |
| SCHEMBL13117549 | 0.83 | CD274 (0.57) | PDCD1CD274KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL13117620 | 0.80 | ALDH1A1 (0.47) | PDCD1CD274TDP1THRBRAD52 | |
| SCHEMBL13117746 | 0.79 | FFAR1 (0.43) | PDCD1CD274ALDH1A1PPARGPPARD | |
| SCHEMBL13117445 | 0.79 | KDM4E (0.46) | PDCD1CD274TDP1THRBKDM4E | |
| SCHEMBL30335600 | 0.79 | CD274 (0.49) | PDCD1CD274CYP4F2CYP4A11KDM4E | |
| SCHEMBL21359629 | 0.79 | CD274 (0.49) | PDCD1CD274CYP4F2CYP4A11KDM4E | |
| SCHEMBL13117630 | 0.78 | CD274 (0.38) | PDCD1CD274CYP4F2CYP4A11RAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100267775-A1 | OXADIAZOLIDINEDIONE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2010-10-21 | — | — | US | disclosed |
| US-20100267775-A1 | OXADIAZOLIDINEDIONE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2010-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267775-A1 | OXADIAZOLIDINEDIONE COMPOUND | GPR119, GLP1R, GPR4 | PDCD1 1246/4885CD274 1333/4885CYP4F2 4442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.