Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | TBK1 | Q9UHD2 | 10/20 | 0.45 |
| ▸ | XDH | P47989 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14384228 | 0.82 | XDH (0.52) | PDE3BPDE3ATBK1XDHKDM4E | |
| SCHEMBL13123181 | 0.72 | ALDH1A1 (0.45) | XDHKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL13626793 | 0.72 | PDE3B (0.46) | PDE3BPDE3ATBK1XDHKDM4E | |
| SCHEMBL13626791 | 0.71 | PDE3B (0.49) | PDE3BPDE3ATBK1XDHKDM4E | |
| SCHEMBL3578305 | 0.69 | MAPK1 (0.55) | PDE3BPDE3AXDHKDM4EALDH1A1 | |
| SCHEMBL5556515 | 0.69 | CNR2 (0.47) | PDE3BPDE3ATBK1XDHROCK2 | |
| SCHEMBL4016605 | 0.68 | ALDH1A1 (0.48) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL28405435 | 0.68 | ALDH1A1 (0.57) | PDE3BPDE3AKDM4EALDH1A1LMNA | |
| SCHEMBL14035954 | 0.66 | MAPK1 (0.51) | PDE3BPDE3ATBK1XDHKDM4E | |
| SCHEMBL28502019 | 0.66 | ACVR1 (0.50) | ALDH1A1LMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820700-B2 | 2-phenylpyridine derivative | ASTELLAS PHARMA INC. (JP) | 2010-10-26 | — | — | US | disclosed |