Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN2 | P17706 | 1/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.59 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.57 |
| ▸ | HTR3B | O95264 | 1/20 | 0.57 |
| ▸ | HTR3A | P46098 | 1/20 | 0.57 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.57 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.57 |
| ▸ | MAPK8 | P45983 | 7/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.43 |
| ▸ | PDE2A | O00408 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30578099 | 0.79 | MAPK8 (0.54) | PTPN2PTPN1HTR3EHTR3BHTR3A | |
| SCHEMBL31746758 | 0.79 | MAPK8 (0.54) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL169235 | 0.79 | MAPK8 (0.54) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL120846 | 0.79 | MAPK8 (0.54) | PTPN2PTPN1HTR3EHTR3BHTR3A | |
| SCHEMBL2816993 | 0.79 | IKBKB (0.68) | PTPN2PTPN1HTR3EHTR3BHTR3A | |
| SCHEMBL15958608 | 0.79 | HTR3E (0.53) | PTPN2PTPN1HTR3EHTR3BHTR3A | |
| SCHEMBL11487184 | 0.79 | HPGD (0.57) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL18096528 | 0.77 | HTR3E (0.39) | PTPN2PTPN1HTR3EHTR3BHTR3A | |
| SCHEMBL11417540 | 0.77 | MAPK8 (0.55) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL12676874 | 0.76 | MAPK8 (0.51) | PTPN2PTPN1HTR3EHTR3BHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8378098-B2 | Imidazol[1,2-α]quinoxalines and derivatives for the treatment of cancers | UNIVERSITE DE MONTPELLIER I (FR) | 2013-02-19 | — | — | US | disclosed |
| US-20100249142-A1 | IMIDAZOL[1,2-alpha]QUINOXALINES AND DERIVATIVES FOR THE TREATMENT OF CANCERS | UNIVERSITE DE MONTPELLIER I | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249142-A1 | IMIDAZOL[1,2-alpha]QUINOXALINES AND DERIVATIVES FOR THE TREATMENT OF CANCERS | IDH3A, NRAS, KRAS | PTPN2 2630/4885PTPN1 2709/4885HTR3E 3105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.