Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.39 |
| ▸ | HTR3B | O95264 | 2/20 | 0.39 |
| ▸ | HTR3A | P46098 | 2/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | ATP4A | P20648 | 1/20 | 0.38 |
| ▸ | ATP4B | P51164 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 2/20 | 0.36 |
| ▸ | PDE6D | O43924 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31531843 | 0.78 | PTPN1 (0.59) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL13131265 | 0.77 | PTPN2 (0.59) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL25706382 | 0.71 | FLT1 (0.39) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL27265682 | 0.70 | HTR3E (0.43) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL9892676 | 0.70 | FLT1 (0.41) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL17557193 | 0.70 | FLT1 (0.41) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL29994225 | 0.70 | FLT1 (0.41) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL11853173 | 0.69 | MEN1 (0.51) | PDE2APDE6DPDE6APDE6GPDE4A | |
| SCHEMBL19036185 | 0.68 | MAPK8 (0.46) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL19606124 | 0.68 | HTR3E (0.41) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3297613-A1 | MESOSCALE NANOPARTICLES FOR SELECTIVE TARGETING TO THE KIDNEY AND METHODS OF THEIR THERAPEUTIC USE | Memorial Sloan Kettering Cancer Center (US) | 2018-03-28 | — | — | EP | disclosed |
| WO-2016153920-A1 | MESOSCALE NANOPARTICLES FOR SELECTIVE TARGETING TO THE KIDNEY AND METHODS OF THEIR THERAPEUTIC USE | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2016-09-29 | — | — | WO | disclosed |