Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.48 |
| ▸ | GAA | P10253 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 8/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3994106 | 0.93 | MEN1 (0.54) | MEN1KMT2AGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL2816533 | 0.91 | SAE1 (0.48) | MEN1KMT2AGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL13133008 | 0.89 | NTRK1 (0.50) | MEN1KMT2ASMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL17957235 | 0.85 | CA12 (0.41) | MEN1KMT2ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL17957293 | 0.84 | CA12 (0.44) | MEN1KMT2AGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL17957271 | 0.83 | RAB9A (0.44) | MEN1KMT2ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL2816165 | 0.82 | COPS5 (0.43) | MEN1KMT2ASMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL13170180 | 0.81 | CA12 (0.42) | SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL13133007 | 0.81 | NR1H4 (0.56) | MEN1KMT2AGAASMN1; SMN2LMNA | |
| SCHEMBL13133015 | 0.80 | CCNC (0.41) | MEN1KMT2AGAASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100249132-A1 | IMIDAZOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249132-A1 | IMIDAZOLE DERIVATIVES | SDHA, SDHB, TPD52L2 | MEN1 171/4885KMT2A 1034/4885GAA 1382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.