Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | C1S | P09871 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 2/20 | 0.34 |
| ▸ | ALPI | P09923 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL577156 | 0.88 | HSD17B1 (0.42) | KDM4EC1SMEN1ALDH1A1KMT2A | |
| SCHEMBL13147660 | 0.86 | IDH1 (0.39) | ADORA2AADORA1KDM4EHSD17B10C1S | |
| SCHEMBL13147664 | 0.84 | ALDH1A1 (0.44) | ADORA2AKDM4EHSD17B10C1SALDH1A1 | |
| SCHEMBL13147740 | 0.83 | IDH1 (0.41) | ADORA2AADORA1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL13147656 | 0.81 | KDM4E (0.47) | ADORA2AKDM4EHSD17B10MEN1ALDH1A1 | |
| SCHEMBL13147675 | 0.80 | IDH1 (0.35) | KDM4EHSD17B10MEN1ALDH1A1KMT2A | |
| SCHEMBL577739 | 0.80 | KDM4E (0.34) | KDM4EHSD17B10C1SMEN1ALDH1A1 | |
| SCHEMBL13147684 | 0.79 | RAB9A (0.41) | ADORA2AADORA1KDM4EHSD17B10C1S | |
| SCHEMBL13147661 | 0.78 | IDH1 (0.37) | KDM4EALDH1A1KMT2AIDH1 | |
| SCHEMBL13147742 | 0.78 | IDH1 (0.37) | ADORA2AADORA1KDM4EHSD17B10IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118078-A1 | MACROCYCLIC SERINE PROTEASE INHIBITORS | IDENIX PHARMACEUTICALS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |