Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | PGR | P06401 | 6/20 | 0.43 |
| ▸ | AR | P10275 | 4/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.42 |
| ▸ | MLNR | O43193 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 8/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | SERPINA6 | P08185 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3408147 | 1.00 | HSP90AA1 (0.55) | HSP90AA1PGRARCHRM1NR3C1 | |
| SCHEMBL3408152 | 1.00 | HSP90AA1 (0.55) | HSP90AA1PGRARCHRM1NR3C1 | |
| SCHEMBL13103471 | 1.00 | HSP90AA1 (0.55) | HSP90AA1PGRARCHRM1NR3C1 | |
| SCHEMBL20068196 | 0.90 | HSP90AA1 (0.45) | HSP90AA1PGRARCHRM1NR3C1 | |
| SCHEMBL13103470 | 0.82 | PGR (0.62) | PGRARCHRM1NR3C1MLNR | |
| SCHEMBL13150963 | 0.82 | PGR (0.62) | PGRARCHRM1NR3C1MLNR | |
| SCHEMBL3406951 | 0.82 | PGR (0.62) | PGRARCHRM1NR3C1MLNR | |
| SCHEMBL13148408 | 0.78 | HIF1A (0.59) | PGRARCHRM1NR3C1KMT2A | |
| SCHEMBL21278181 | 0.78 | HIF1A (0.59) | PGRARCHRM1NR3C1KMT2A | |
| SCHEMBL16613937 | 0.78 | HIF1A (0.59) | PGRARCHRM1NR3C1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010114473-A1 | NOVEL STEROIDAL[3,2-C]PYRAZOL DERIVATIVES WITH GLUCOCORTICOID ACTIVITY | ASTRAZENECA AB (SE) | 2010-10-07 | — | — | WO | disclosed |