Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 6/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.41 |
| ▸ | MLNR | O43193 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 11/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | SERPINA6 | P08185 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SHBG | P04278 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3408152 | 0.90 | HSP90AA1 (0.55) | HSP90AA1PGRNR3C1NR1I2MLNR | |
| SCHEMBL13150608 | 0.90 | HSP90AA1 (0.55) | HSP90AA1PGRNR3C1NR1I2MLNR | |
| SCHEMBL3408147 | 0.90 | HSP90AA1 (0.55) | HSP90AA1PGRNR3C1NR1I2MLNR | |
| SCHEMBL13103471 | 0.90 | HSP90AA1 (0.55) | HSP90AA1PGRNR3C1NR1I2MLNR | |
| SCHEMBL21278127 | 0.87 | PGR (0.42) | PGRNR3C1NR1I2MLNRADORA3 | |
| SCHEMBL16613937 | 0.77 | HIF1A (0.59) | PGRNR3C1HIF1ALMNAHSD17B10 | |
| SCHEMBL21278181 | 0.77 | HIF1A (0.59) | PGRNR3C1HIF1ALMNAHSD17B10 | |
| SCHEMBL13148408 | 0.77 | HIF1A (0.59) | PGRNR3C1HIF1ALMNAHSD17B10 | |
| SCHEMBL21278264 | 0.76 | NR3C1 (0.35) | PGRNR3C1NR1I2MLNRADORA3 | |
| SCHEMBL3403977 | 0.76 | HIF1A (0.59) | PGRNR3C1NR1I2HIF1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071736-A1 | STRUCTURES AND MECHANISM FOR THE DESIGN OF HIGHLY POTENT GLUCOCORTICOIDS | VAN ANDEL RESEARCH INSTITUTE (US) | 2018-04-19 | — | — | WO | disclosed |