Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | TACR1 | P25103 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | MC4R | P32245 | 2/20 | 0.45 |
| ▸ | MC3R | P41968 | 2/20 | 0.45 |
| ▸ | MC1R | Q01726 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9600780 | 0.84 | TACR3 (0.67) | TACR3ALDH1A1POLBSMN1; SMN2LMNA | |
| SCHEMBL12794066 | 0.79 | HSD11B1 (0.56) | TACR3POLBHSD11B1TACR1HPGD | |
| SCHEMBL5037841 | 0.78 | TACR3 (0.64) | TACR3ALDH1A1POLBHSD11B1SMN1; SMN2 | |
| SCHEMBL14263092 | 0.78 | TACR3 (0.59) | TACR3ALDH1A1HSD11B1L3MBTL1KCNH2 | |
| SCHEMBL31324479 | 0.77 | TACR3 (0.62) | TACR3ALDH1A1HSD11B1TACR1SMN1; SMN2 | |
| SCHEMBL25139677 | 0.77 | ALDH1A1 (0.59) | TACR3ALDH1A1POLBHSD11B1SMN1; SMN2 | |
| SCHEMBL12384538 | 0.77 | ALDH1A1 (0.59) | TACR3ALDH1A1POLBHSD11B1SMN1; SMN2 | |
| SCHEMBL5034424 | 0.76 | TACR3 (0.59) | TACR3ALDH1A1POLBHSD11B1SMN1; SMN2 | |
| SCHEMBL15014630 | 0.75 | ALDH1A1 (0.75) | TACR3ALDH1A1POLBSMN1; SMN2LMNA | |
| SCHEMBL21138804 | 0.75 | HSD11B1 (0.62) | TACR3ALDH1A1HSD11B1TACR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120889-A1 | TREATMENT OF METABOLIC SYNDROME WITH CYCLIC AMIDES | AMPLA PHARMACEUTICALS INC. (US) | 2010-10-21 | — | — | WO | disclosed |