Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 3/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13152593 | 0.86 | LMNA (0.50) | LMNACYP19A1CYP2C19ABCC2HTR2A | |
| SCHEMBL13153383 | 0.79 | KCNA3 (0.38) | CNR1HTR6 | |
| SCHEMBL24143782 | 0.78 | HTR2A (0.43) | LMNACHEK1CYP19A1CYP2C19HTR2A | |
| SCHEMBL13153386 | 0.77 | KIF11 (0.44) | LMNACNR1CNR2HTR1AHTR7 | |
| SCHEMBL13806215 | 0.77 | CHEK1 (0.43) | CHEK1PDGFRACDK5TYRO3RAB9A | |
| SCHEMBL10095347 | 0.76 | SMN1; SMN2 (0.47) | LMNA | |
| SCHEMBL13806314 | 0.74 | NR4A2 (0.50) | LMNACYP19A1NPC1RAB9A | |
| SCHEMBL13152564 | 0.73 | DYRK1A (0.43) | LMNACYP19A1CNR1CNR2ABCC2 | |
| SCHEMBL13152546 | 0.73 | CYP1A2 (0.41) | CYP2C19HTR1ANPC1RAB9A | |
| SCHEMBL25742135 | 0.72 | LMNA (0.47) | LMNAPDGFRACDK5TYRO3CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118009-A1 | HCV INHIBITOR AND THERAPEUTIC AGENT COMBINATIONS | PTC THERAPEUTICS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |