Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | RHOA | P61586 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | VDR | P11473 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13152811 | 0.91 | SMN1; SMN2 (0.38) | LMNAHTTMAPTGAAMAPK1 | |
| SCHEMBL10096104 | 0.89 | LMNA (0.38) | LMNAHTTHPGDMAPTVDR | |
| SCHEMBL13152794 | 0.89 | F11 (0.34) | CHRM2CHRM1CHRM3HTR3AVDR | |
| SCHEMBL12995281 | 0.87 | P2RX3 (0.36) | LMNAHTTHPGDP2RX3 | |
| SCHEMBL13152823 | 0.87 | IDO1 (0.36) | MAPK14HTR1DHTR3ALPAR1GAA | |
| SCHEMBL13152798 | 0.86 | IDO1 (0.36) | HPGDHTR3ANPC1RAB9A | |
| SCHEMBL13152796 | 0.86 | POLB (0.33) | HTR3ALPAR1TP53 | |
| SCHEMBL10096068 | 0.85 | LMNA (0.39) | LMNAHTTHPGDMAPTVDR | |
| SCHEMBL13152787 | 0.84 | HTR3A (0.32) | HTR3ALPAR1 | |
| SCHEMBL14466389 | 0.83 | HTR3A (0.36) | HTR3ALPAR1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118009-A1 | HCV INHIBITOR AND THERAPEUTIC AGENT COMBINATIONS | PTC THERAPEUTICS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |