SCHEMBL1315440

SCHEMBL1315440

O=C(Nc1cc(-c2cccc(F)c2)ccc1C(=O)O)c1cc(N2CCOCC2)ccc1O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKDC P78527 2/20 0.43
PIK3CD O00329 1/20 0.43
PIK3CA P42336 1/20 0.43
PIK3CB P42338 1/20 0.43
PIK3CG P48736 1/20 0.43
HDAC1 Q13547 1/20 0.43
SCN9A Q15858 1/20 0.42
MCL1 Q07820 2/20 0.42
ACLY P53396 1/20 0.42
F10 P00742 1/20 0.42
RAB9A P51151 4/20 0.42
NPC1 O15118 3/20 0.41
ALB P02768 1/20 0.41
NTRK1 P04629 2/20 0.41
KMO O15229 1/20 0.41
MAPT P10636 3/20 0.41
ALDH1A1 P00352 2/20 0.41
MEN1 O00255 1/20 0.41
HPGD P15428 1/20 0.41
NFKB1 P19838 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1316184 0.91 HDAC1 (0.45) PRKDCPIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL1315851 0.91 HDAC1 (0.51) PRKDCPIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL1315963 0.90 MAPT (0.46) HDAC1ACLYF10RAB9ANPC1
Hydrochloric Acid SCHEMBL1318051 0.90 HDAC1 (0.50) PRKDCPIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL1315061 0.89 MCL1 (0.46) PRKDCPIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL1318044 0.88 MCL1 (0.49) PRKDCPIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL27989050 0.86 AOC3 (0.47) PRKDCPIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL1316558 0.86 MEN1 (0.52) PIK3CAMCL1ACLYALBNTRK1
SCHEMBL1318077 0.86 ACMSD (0.50) PRKDCPIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL1315586 0.85 MEN1 (0.52) PRKDCPIK3CDPIK3CAPIK3CBPIK3CG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102333757-B N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO LTD 2014-11-26 CN disclosed
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 US disclosed
EP-2385036-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF Toyama Chemical Co., Ltd. (JP) 2011-11-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF COL14A1, COL2A1, COL1A1 PRKDC 4305/4885PIK3CD 4764/4885PIK3CA 4580/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.