Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 12/20 | 0.54 |
| ▸ | SCN1A | P35498 | 9/20 | 0.54 |
| ▸ | SCN5A | Q14524 | 9/20 | 0.54 |
| ▸ | SCN1B | Q07699 | 7/20 | 0.54 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.52 |
| ▸ | SCN4A | P35499 | 1/20 | 0.52 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.52 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.52 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | EDNRA | P25101 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1350297 | 0.89 | SCN8A (0.56) | SCN8ASCN1ASCN5ASCN1BSCN3A | |
| SCHEMBL13154447 | 0.85 | SCN8A (0.65) | SCN8ASCN1ASCN5ASCN1BSCN3A | |
| SCHEMBL13154433 | 0.77 | SCN1A (0.62) | SCN8ASCN1ASCN5ASCN1BSCN3A | |
| SCHEMBL326633 | 0.73 | ALDH1A1 (0.71) | SCN8ASCN1ASCN5ASCN1BSCN3A | |
| Hydrochloric Acid SCHEMBL27575105 | 0.72 | ALDH1A1 (0.69) | SCN8ASCN1ASCN5ASCN1BSCN3A | |
| SCHEMBL3070565 | 0.71 | ALDH1A1 (0.68) | SCN8ASCN1ASCN5ASCN1BSCN3A | |
| SCHEMBL710141 | 0.71 | ALDH1A1 (0.56) | LMNAALDH1A1KDM4ECYP2C9EDNRA | |
| SCHEMBL20238762 | 0.70 | SCN8A (1.00) | SCN8ASCN1ASCN5ASCN1BSCN3A | |
| SCHEMBL20238763 | 0.70 | SCN8A (1.00) | SCN8ASCN1ASCN5ASCN1BSCN3A | |
| SCHEMBL13154443 | 0.70 | SCN8A (0.49) | SCN8ASCN1ASCN5ASCN1BSCN3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8338608-B2 | Inhibitors of ion channels | ICAGEN INC. (US) | 2012-12-25 | — | — | US | disclosed |
| US-8338608-B2 | Inhibitors of ion channels | ICAGEN INC. (US) | 2012-12-25 | — | — | US | disclosed |
| US-20100234343-A1 | INHIBITORS OF ION CHANNELS | ICAGEN, INC. (US) | 2010-09-16 | — | — | US | disclosed |
| US-20100234343-A1 | INHIBITORS OF ION CHANNELS | ICAGEN, INC. (US) | 2010-09-16 | — | — | US | disclosed |
| US-7705158-B2 | Inhibitors of ion channels | ICAGEN, INC. (US) | 2010-04-27 | — | — | US | disclosed |
| US-7705158-B2 | Inhibitors of ion channels | ICAGEN, INC. (US) | 2010-04-27 | — | — | US | disclosed |
| US-20070135493-A1 | INHIBITORS OF ION CHANNELS | ICAGEN (US) | 2007-06-14 | — | — | US | disclosed |
| US-20070135493-A1 | INHIBITORS OF ION CHANNELS | ICAGEN (US) | 2007-06-14 | — | — | US | disclosed |
| WO-2007056099-A2 | INHIBITORS OF ION CHANNELS | ICAGEN, INC. (US) | 2007-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234343-A1 | INHIBITORS OF ION CHANNELS | TRPV1, TRPV5, TRPA1 | SCN8A 75/4885SCN1A 6/4885SCN5A 15/4885 |
| US-20070135493-A1 | INHIBITORS OF ION CHANNELS | TRPV1, TRPV5, TRPA1 | SCN8A 75/4885SCN1A 6/4885SCN5A 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.