SCHEMBL1315545

SCHEMBL1315545

CN1CCN(c2ccc(OCc3ccccc3)c(C(=O)Nc3cc(-c4ccccc4)ccc3C(=O)OC(C)(C)C)c2)CC1

nearest known ligand 0.58

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
LRRK2 Q5S007 12/20 0.58
CYP3A4 P08684 2/20 0.49
SLCO1B1 Q9Y6L6 2/20 0.49
KCNH2 Q12809 1/20 0.49
HTR6 P50406 4/20 0.49
HDAC3 O15379 1/20 0.46
HDAC2 Q92769 1/20 0.46
WDR5 P61964 1/20 0.44
USP2 O75604 1/20 0.44
MAPT P10636 1/20 0.44
MAPK1 P28482 1/20 0.44
KMT2A Q03164 1/20 0.44
ESR2 Q92731 1/20 0.44
TAAR1 Q96RJ0 1/20 0.44
ALDH1A1 P00352 1/20 0.44
GAA P10253 1/20 0.44
TSHR P16473 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1316332 0.93 LRRK2 (0.56) LRRK2CYP3A4SLCO1B1KCNH2
SCHEMBL1316798 0.91 LRRK2 (0.57) LRRK2CYP3A4SLCO1B1KCNH2KMT2A
SCHEMBL1317027 0.91 LRRK2 (0.47) LRRK2CYP3A4SLCO1B1KCNH2
SCHEMBL1316012 0.91 LRRK2 (0.58) LRRK2CYP3A4SLCO1B1KCNH2
SCHEMBL1315355 0.88 LRRK2 (0.48) LRRK2CYP3A4SLCO1B1KCNH2
SCHEMBL1316248 0.88 LRRK2 (0.47) LRRK2CYP3A4SLCO1B1KCNH2
SCHEMBL1316412 0.87 ABCG2 (0.44) LRRK2CYP3A4SLCO1B1KCNH2WDR5
SCHEMBL1317921 0.87 LRRK2 (0.49) LRRK2CYP3A4SLCO1B1
SCHEMBL1319536 0.86 LRRK2 (0.48) LRRK2CYP3A4SLCO1B1KCNH2
SCHEMBL1317817 0.86 MET (0.47) LRRK2CYP3A4SLCO1B1KCNH2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102333757-B N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO LTD 2014-11-26 CN disclosed
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 US disclosed
EP-2385036-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF Toyama Chemical Co., Ltd. (JP) 2011-11-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF COL14A1, COL2A1, COL1A1 LRRK2 1813/4885CYP3A4 3293/4885SLCO1B1 4408/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.