Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 5/20 | 0.66 |
| ▸ | JAK2 | O60674 | 3/20 | 0.66 |
| ▸ | JAK1 | P23458 | 3/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 1/20 | 0.52 |
| ▸ | PIK3C3 | Q8NEB9 | 4/20 | 0.51 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.49 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.49 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16840724 | 0.89 | TYK2 (0.60) | TYK2JAK2JAK1L3MBTL1MAPKAPK2 | |
| SCHEMBL19728663 | 0.87 | TYK2 (0.64) | TYK2JAK2JAK1L3MBTL1MAPKAPK2 | |
| SCHEMBL11371375 | 0.85 | NPC1 (0.60) | TYK2JAK2JAK1MAPKAPK2BRAF | |
| SCHEMBL12975420 | 0.83 | L3MBTL1 (0.55) | TYK2JAK2JAK1L3MBTL1MAPKAPK2 | |
| SCHEMBL10264295 | 0.83 | L3MBTL1 (0.55) | TYK2JAK2JAK1L3MBTL1BRAF | |
| SCHEMBL24951596 | 0.83 | TYK2 (0.53) | TYK2JAK2JAK1L3MBTL1MAPKAPK2 | |
| SCHEMBL30202790 | 0.83 | TYK2 (0.53) | TYK2JAK2JAK1L3MBTL1MAPKAPK2 | |
| SCHEMBL197857 | 0.82 | KDM5A (0.54) | TYK2JAK2JAK1L3MBTL1KDM4E | |
| SCHEMBL19736273 | 0.82 | TYK2 (0.52) | TYK2JAK2JAK1L3MBTL1MAPKAPK2 | |
| SCHEMBL5520229 | 0.81 | KDM4E (0.49) | TYK2JAK2JAK1L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170362234-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-12-21 | — | — | US | disclosed |
| US-7803804-B2 | Substituted pyrazines for use in the treatment of inflammatory or allergic conditions | NOVARTIS AG (CH) | 2010-09-28 | — | — | US | disclosed |
| US-7803804-B2 | Substituted pyrazines for use in the treatment of inflammatory or allergic conditions | NOVARTIS AG (CH) | 2010-09-28 | — | — | US | disclosed |
| US-20080312217-A1 | Organic Compounds | NOVARTIS AG | 2008-12-18 | — | — | US | disclosed |
| US-20080312217-A1 | Organic Compounds | NOVARTIS AG | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170362234-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | TYK2 2258/4885JAK2 1856/4885JAK1 2463/4885 |
| US-20080312217-A1 | Organic Compounds | TRPA1, TRPV1, CHRM1 | TYK2 1776/4885JAK2 1706/4885JAK1 1697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.