Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGA | O60502 | 11/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13168224 | 0.83 | OGA (0.46) | OGATSHRTMEM97LRRK2GAA | |
| SCHEMBL14996505 | 0.80 | OGA (0.43) | OGATSHRTMEM97LRRK2ALDH1A1 | |
| SCHEMBL13131064 | 0.77 | OGA (0.42) | OGATSHRTMEM97LRRK2FFAR4 | |
| SCHEMBL12944876 | 0.77 | CYP2C9 (0.52) | TSHRALDH1A1 | |
| SCHEMBL11955033 | 0.74 | KMT2A (0.51) | ALDH1A1GAARAD52 | |
| SCHEMBL13168229 | 0.73 | PHGDH (0.41) | OGATSHRGAARAD52 | |
| SCHEMBL13168325 | 0.72 | CHRNB2 (0.50) | — | |
| SCHEMBL20468836 | 0.72 | OGA (0.48) | OGATSHRLRRK2ALDH1A1 | |
| SCHEMBL11956175 | 0.72 | CYP2D6 (0.53) | TSHRALDH1A1 | |
| SCHEMBL22359000 | 0.72 | TSHR (0.59) | TSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100249095-A1 | Substituted Spiro-amide Compounds | GRUENENTHAL GMBH (DE) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249095-A1 | Substituted Spiro-amide Compounds | BDKRB1, BDKRB2, REN | OGA 3406/4885TSHR 338/4885TMEM97 1662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.