Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 4/20 | 0.39 |
| ▸ | USP2 | O75604 | 3/20 | 0.39 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | OGA | O60502 | 6/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.36 |
| ▸ | TSHR | P16473 | 5/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13168260 | 0.83 | SMN1; SMN2 (0.51) | CYP2C9CXCR3CYP2C19CYP1A2HPGD | |
| SCHEMBL14996529 | 0.83 | CYP3A4 (0.43) | CYP2C9USP2CXCR3PPARGPPARD | |
| SCHEMBL26125332 | 0.82 | KCNH2 (0.46) | CYP2C9USP2PPARGPPARDPPARA | |
| SCHEMBL26127806 | 0.81 | SMN1; SMN2 (0.43) | CYP2C9USP2PPARGPPARDPPARA | |
| SCHEMBL30286314 | 0.81 | PARP1 (0.44) | CYP2C9USP2PPARGPPARDPPARA | |
| SCHEMBL11956175 | 0.80 | CYP2D6 (0.53) | CYP2C9USP2CYP2D6TSHRCYP2C19 | |
| SCHEMBL13131096 | 0.80 | USP2 (0.40) | CYP2C9USP2CXCR3PPARGPPARD | |
| SCHEMBL26126183 | 0.79 | PPARG (0.41) | CYP2C9USP2PPARGPPARDPPARA | |
| SCHEMBL11955829 | 0.78 | CA12 (0.43) | PPARDPPARACYP2D6TSHRCYP3A4 | |
| SCHEMBL484575 | 0.75 | USP2 (0.52) | CYP2C9USP2CYP2D6TSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100249095-A1 | Substituted Spiro-amide Compounds | GRUENENTHAL GMBH (DE) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249095-A1 | Substituted Spiro-amide Compounds | BDKRB1, BDKRB2, REN | CYP2C9 2259/4885USP2 4864/4885CXCR3 168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.