Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3106296 | 0.89 | AKR1C3 (0.66) | AKR1C3KMT2AMEN1RAB9ARXFP1 | |
| SCHEMBL13173678 | 0.88 | PTGS2 (0.56) | AKR1C3KMT2AMEN1RAB9ARXFP1 | |
| SCHEMBL13174697 | 0.85 | AKR1C3 (0.52) | AKR1C3KMT2AMEN1BRD3KDM4E | |
| SCHEMBL13174669 | 0.85 | AKR1C3 (0.61) | AKR1C3KMT2AMEN1LMNAMAPT | |
| SCHEMBL24196942 | 0.81 | PTGS2 (0.59) | KMT2AMEN1RAB9ARXFP1CNR1 | |
| SCHEMBL3106490 | 0.79 | AKR1C3 (0.78) | AKR1C3KMT2AMEN1 | |
| SCHEMBL24196836 | 0.78 | MAPT (0.61) | KMT2AMEN1RAB9ARXFP1CNR1 | |
| SCHEMBL13174666 | 0.77 | AKR1C3 (0.74) | AKR1C3KMT2AMEN1 | |
| SCHEMBL13174707 | 0.76 | AKR1C3 (0.59) | AKR1C3KMT2AMEN1MAPTKDM4E | |
| SCHEMBL13174680 | 0.76 | KMT2A (0.53) | AKR1C3KMT2AMEN1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010101127-A1 | INDOLE COMPOUND | アステラス製薬株式会社 (JP) | 2010-09-10 | — | — | WO | disclosed |