Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 3/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.42 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.42 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12206558 | 1.00 | GLS (0.47) | GLSRAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL2636114 | 0.88 | NQO2 (0.46) | GLSRAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL209838 | 0.85 | GLS (0.52) | GLSBRD4KDM4ANAMPTCREBBP | |
| SCHEMBL29952891 | 0.85 | GLS (0.52) | GLSBRD4KDM4ANAMPTCREBBP | |
| SCHEMBL3862899 | 0.84 | LMNA (0.42) | GLSSMN1; SMN2KDM4EALDH1A1PKM | |
| SCHEMBL3862895 | 0.84 | LMNA (0.42) | GLSSMN1; SMN2KDM4EALDH1A1PKM | |
| SCHEMBL3243218 | 0.84 | NAMPT (0.49) | RAB9ANPC1MAPTSMN1; SMN2NAMPT | |
| SCHEMBL3243222 | 0.84 | NAMPT (0.49) | RAB9ANPC1MAPTSMN1; SMN2NAMPT | |
| SCHEMBL25370290 | 0.82 | GLS (0.47) | GLSBRD4KDM4ANAMPTCREBBP | |
| SCHEMBL8985043 | 0.82 | MMP1 (0.51) | GLSSMN1; SMN2BRD4KDM4ACREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450459-B2 | IL-21 derivatives and variants | NOVO NORDISK A/S (DK) | 2013-05-28 | — | — | US | disclosed |
| US-8450459-B2 | IL-21 derivatives and variants | NOVO NORDISK A/S (DK) | 2013-05-28 | — | — | US | disclosed |
| EP-1673387-B1 | IL-21 DERIVATIVES | NOVO NORDISK AS (DK) | 2010-09-15 | — | — | EP | disclosed |
| US-20090253864-A1 | IL-21 Derivatives and Variants | NOVO NORDISK A/S (DK) | 2009-10-08 | — | — | US | disclosed |
| US-20090253864-A1 | IL-21 Derivatives and Variants | NOVO NORDISK A/S (DK) | 2009-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253864-A1 | IL-21 Derivatives and Variants | IL2, IL15, IL23R | GLS 1995/4885RAB9A 1558/4885NPC1 1832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.