Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.51 |
| ▸ | PARP11 | Q9NR21 | 3/20 | 0.51 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | PRKACG | P22612 | 1/20 | 0.37 |
| ▸ | PRKACB | P22694 | 1/20 | 0.37 |
| ▸ | S100A4 | P26447 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1727165 | 0.81 | PARP11 (0.72) | NPC1RAB9AMAPTPARP10PARP11 | |
| SCHEMBL15106295 | 0.76 | RAB9A (0.77) | NPC1RAB9AMAPTPARP10PARP11 | |
| SCHEMBL2610325 | 0.76 | MAPT (0.58) | NPC1RAB9AMAPTPARP10PARP11 | |
| SCHEMBL13186574 | 0.74 | PARP10 (0.47) | PARP10PARP11SRD5A1 | |
| SCHEMBL11808846 | 0.72 | MAPT (0.50) | NPC1RAB9AMAPTPARP10PARP11 | |
| SCHEMBL13187114 | 0.72 | PARP10 (0.38) | MAPTPARP10PARP11KMT2AMEN1 | |
| SCHEMBL14395011 | 0.72 | PARP10 (0.61) | NPC1RAB9AMAPTPARP10PARP11 | |
| SCHEMBL1790024 | 0.70 | NPC1 (0.56) | NPC1RAB9AMAPTHSD17B1 | |
| SCHEMBL8253223 | 0.70 | NPC1 (0.61) | NPC1RAB9AMAPTPARP10PARP11 | |
| SCHEMBL29809406 | 0.69 | SRD5A2 (0.72) | NPC1RAB9AMAPTHSD17B1S100A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100070-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2010-09-10 | — | — | WO | disclosed |