Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 7/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GPR52 | Q9Y2T5 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13187149 | 0.91 | RAF1 (0.40) | RAF1GPR52ALDH1A1CNR2 | |
| SCHEMBL13187148 | 0.91 | RAF1 (0.40) | RAF1GPR52ALDH1A1CNR2 | |
| SCHEMBL13187141 | 0.85 | RAF1 (0.47) | RAF1 | |
| SCHEMBL13187145 | 0.85 | RAF1 (0.40) | RAF1ALOX15TSHRCASP1NPSR1 | |
| SCHEMBL13187587 | 0.84 | PLG (0.46) | RAF1GPR52PLGPLAUPLAT | |
| SCHEMBL1726200 | 0.83 | RAF1 (0.42) | RAF1TSHRPLGPLAUPLAT | |
| SCHEMBL13187650 | 0.83 | ALOX15 (0.39) | RAF1ALOX15TSHRCASP1NPSR1 | |
| SCHEMBL13187856 | 0.79 | TSHR (0.59) | ALOX15TSHRCASP1NPSR1HSD17B10 | |
| SCHEMBL13187647 | 0.77 | GRM5 (0.36) | RAF1NTRK1 | |
| SCHEMBL13187665 | 0.77 | GRM5 (0.36) | RAF1NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010101949-A1 | 8-SUBSTITUTED QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2010-09-10 | — | — | WO | disclosed |