Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 7/20 | 0.40 |
| ▸ | GPR52 | Q9Y2T5 | 3/20 | 0.39 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | CTSA | P10619 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13187149 | 1.00 | RAF1 (0.40) | RAF1GPR52SORT1ALDH1A1CNR2 | |
| SCHEMBL13187649 | 0.91 | RAF1 (0.39) | RAF1GPR52ALDH1A1CNR2 | |
| SCHEMBL13187141 | 0.87 | RAF1 (0.47) | RAF1SORT1 | |
| SCHEMBL13187145 | 0.87 | RAF1 (0.40) | RAF1GPR52ALDH1A1 | |
| SCHEMBL13187587 | 0.86 | PLG (0.46) | RAF1GPR52 | |
| SCHEMBL1726200 | 0.85 | RAF1 (0.42) | RAF1 | |
| SCHEMBL13187665 | 0.80 | GRM5 (0.36) | RAF1 | |
| SCHEMBL13187647 | 0.80 | GRM5 (0.36) | RAF1 | |
| SCHEMBL13187650 | 0.80 | ALOX15 (0.39) | RAF1CNR2 | |
| SCHEMBL1035266 | 0.80 | GPR52 (0.44) | RAF1GPR52ALDH1A1CNR2CTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010101949-A1 | 8-SUBSTITUTED QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2010-09-10 | — | — | WO | disclosed |