Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 4/20 | 0.38 |
| ▸ | CCNC | P24863 | 3/20 | 0.36 |
| ▸ | CDK8 | P49336 | 3/20 | 0.36 |
| ▸ | TOP2A | P11388 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 3/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | PLAT | P00750 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13187649 | 0.83 | RAF1 (0.39) | ALOX15TSHRCASP1NPSR1HSD17B10 | |
| SCHEMBL1725040 | 0.81 | TSHR (0.58) | ALOX15TSHRCASP1NPSR1HSD17B10 | |
| SCHEMBL13187145 | 0.80 | RAF1 (0.40) | ALOX15TSHRCASP1NPSR1HSD17B10 | |
| SCHEMBL13187234 | 0.80 | MPL (0.47) | ALOX15TSHRCASP1NPSR1HSD17B10 | |
| SCHEMBL13187148 | 0.80 | RAF1 (0.40) | RAF1CNR2 | |
| SCHEMBL13187149 | 0.80 | RAF1 (0.40) | RAF1CNR2 | |
| SCHEMBL13187860 | 0.79 | TLR7 (0.47) | ALOX15TSHRCASP1NPSR1HSD17B10 | |
| SCHEMBL13187131 | 0.79 | SORT1 (0.48) | ALOX15TSHRCASP1NPSR1HSD17B10 | |
| SCHEMBL13187647 | 0.79 | GRM5 (0.36) | RAF1CCNCCDK8GSK3AGSK3B | |
| SCHEMBL13187665 | 0.79 | GRM5 (0.36) | RAF1CCNCCDK8GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010101949-A1 | 8-SUBSTITUTED QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2010-09-10 | — | — | WO | disclosed |