Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 10/20 | 0.62 |
| ▸ | DYRK1A | Q13627 | 10/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | WNT1 | P04628 | 1/20 | 0.45 |
| ▸ | WNT3A | P56704 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13188627 | 0.89 | GSK3B (0.61) | GSK3BDYRK1A | |
| SCHEMBL13188493 | 0.81 | HDAC3 (0.57) | GSK3BDYRK1AHDAC6 | |
| SCHEMBL13188617 | 0.80 | HDAC6 (0.50) | HDAC6 | |
| SCHEMBL13188515 | 0.79 | HDAC6 (0.45) | HDAC6WNT3A | |
| SCHEMBL13188377 | 0.79 | WNT3A (0.49) | DYRK1AHDAC6WNT3AKMT2A | |
| SCHEMBL13187833 | 0.79 | ADORA3 (0.53) | HDAC6 | |
| SCHEMBL13188800 | 0.79 | HDAC1 (0.55) | HDAC6 | |
| SCHEMBL3717846 | 0.78 | GSK3B (0.51) | GSK3BDYRK1AWNT1 | |
| SCHEMBL13188334 | 0.78 | HDAC6 (0.43) | GSK3BHDAC6WNT3AKMT2A | |
| SCHEMBL13188396 | 0.77 | DYRK1A (0.57) | GSK3BDYRK1AHDAC6TSHRJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |