Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3714261 | 0.94 | DYRK1A (0.54) | DYRK1AHDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL13188616 | 0.90 | DYRK1A (0.56) | DYRK1AHDAC1NPC1RAB9AHIF1A | |
| SCHEMBL3710585 | 0.85 | DYRK1A (0.53) | DYRK1ANPC1RAB9AHIF1AEPAS1 | |
| SCHEMBL13187973 | 0.85 | HDAC1 (0.55) | DYRK1AHDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL13188892 | 0.82 | HDAC6 (0.52) | DYRK1AHDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL13188322 | 0.80 | LMNA (0.53) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL3710589 | 0.79 | HDAC1 (0.49) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL13188605 | 0.79 | HDAC6 (0.58) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL13188494 | 0.79 | HDAC6 (0.58) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL13188442 | 0.77 | GSK3B (0.62) | DYRK1AHDAC6GSK3BJAK3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |