Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13691772 | 0.89 | OPRM1 (0.46) | NPC1OPRM1TMEM97SIGMAR1DRD2 | |
| SCHEMBL13691769 | 0.88 | OPRM1 (0.46) | NPC1OPRM1TMEM97SIGMAR1DRD2 | |
| SCHEMBL13689401 | 0.87 | OPRM1 (0.45) | NPC1OPRM1TMEM97SIGMAR1DRD2 | |
| SCHEMBL13691793 | 0.85 | NPC1 (0.47) | NPC1OPRM1TMEM97SIGMAR1DRD2 | |
| SCHEMBL13691768 | 0.85 | OPRM1 (0.45) | NPC1OPRM1TMEM97SIGMAR1DRD2 | |
| SCHEMBL13691797 | 0.84 | DRD2 (0.54) | OPRM1TMEM97SIGMAR1DRD2DRD3 | |
| SCHEMBL13189116 | 0.84 | UTS2R (0.39) | NPC1OPRM1TMEM97SIGMAR1DRD2 | |
| SCHEMBL13689397 | 0.83 | CXCR4 (0.43) | NPC1OPRM1TMEM97SIGMAR1DRD2 | |
| SCHEMBL13691763 | 0.82 | TMEM97 (0.46) | NPC1OPRM1TMEM97SIGMAR1DRD2 | |
| SCHEMBL13691662 | 0.82 | TMEM97 (0.47) | NPC1TMEM97SIGMAR1HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010096854-A1 | METHODS OF MODULATING THE ACTIVITY OF THE MC3 AND/OR MC4 RECEPTORS AND TREATMENT OF CONDITIONS RELATED TO THESE RECEPTORS | MIMETICA PTY LTD (AU) | 2010-09-02 | — | — | WO | disclosed |
| WO-2009105824-A1 | METHODS OF MODULATING THE ACTIVITY OF THE MC5 RECEPTOR AND TREATMENT OF CONDITIONS RELATED TO THIS RECEPTOR | MIMETICA PTY LTD (AU) | 2009-09-03 | — | — | WO | disclosed |