Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KHK | P50053 | 4/20 | 0.50 |
| ▸ | KDM1A | O60341 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | USP1 | O94782 | 1/20 | 0.46 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | METAP2 | P50579 | 1/20 | 0.46 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.44 |
| ▸ | CCR8 | P51685 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3876083 | 0.83 | NSD2 (0.48) | KHKKDM1AMAOBMAPTUSP1 | |
| SCHEMBL10980089 | 0.81 | P2RX7 (0.54) | MAPTHTTL3MBTL1METAP2MEN1 | |
| SCHEMBL29588425 | 0.77 | HTT (0.52) | MAPTHTTL3MBTL1MEN1KMT2A | |
| SCHEMBL26268468 | 0.75 | POLB (0.49) | KDM1ACYP2C19GAAMEN1KMT2A | |
| SCHEMBL178537 | 0.73 | CARM1 (0.50) | KDM1AMAOBMAPTUSP1WDR48 | |
| SCHEMBL13118523 | 0.73 | GRIN2B (0.57) | KDM1AMAOBUSP1WDR48 | |
| SCHEMBL13518359 | 0.72 | HTT (0.47) | MAPTHTTL3MBTL1KMT2A | |
| SCHEMBL13162894 | 0.72 | HTR7 (0.60) | MAPTCCR8 | |
| SCHEMBL15692576 | 0.71 | ACHE (0.50) | ACHECYP2C19KMT2A | |
| SCHEMBL23028601 | 0.71 | CCNT1 (0.47) | KDM1AMAOBL3MBTL1USP1WDR48 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010107605-A1 | CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2010-09-23 | — | — | WO | disclosed |