Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | APP | P05067 | 13/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.64 |
| ▸ | USP1 | O94782 | 1/20 | 0.63 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3114782 | 0.86 | PDE5A (0.67) | PDE5AMAPTNPSR1APPMEN1 | |
| SCHEMBL7493587 | 0.85 | PDE5A (0.69) | PDE5AAPPMEN1KMT2AALDH1A1 | |
| SCHEMBL7496663 | 0.82 | PDE5A (0.71) | PDE5AMAPTNPSR1MEN1KMT2A | |
| SCHEMBL5137740 | 0.81 | PDE5A (1.00) | PDE5AMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL30454922 | 0.79 | MAPT (0.59) | PDE5AMAPTNPSR1MEN1KMT2A | |
| SCHEMBL13009791 | 0.79 | APP (1.00) | PDE5AMAPTNPSR1APPMEN1 | |
| SCHEMBL2453907 | 0.78 | KCNH2 (0.54) | PDE5AMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL12120503 | 0.78 | PDE5A (0.55) | PDE5AMEN1KMT2AALDH1A1 | |
| SCHEMBL14256686 | 0.76 | PDE5A (0.55) | PDE5AMAPTNPSR1MEN1KMT2A | |
| SCHEMBL30455233 | 0.76 | MEN1 (0.58) | PDE5AMAPTNPSR1APPMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120258975-A1 | Potent Small Molecule Inhibitors of Autophagy, and Methods of Use Thereof | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY (CN) | 2012-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120258975-A1 | Potent Small Molecule Inhibitors of Autophagy, and Methods of Use Thereof | ATG7, BECN1, SQSTM1 | PDE5A 3288/4885MAPT 1917/4885NPSR1 4655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.