Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 18/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12989767 | 1.00 | EPHX2 (0.64) | EPHX2 | |
| SCHEMBL15686636 | 0.90 | EPHX2 (0.53) | EPHX2 | |
| SCHEMBL17278728 | 0.90 | EPHX2 (0.58) | EPHX2 | |
| SCHEMBL15644293 | 0.80 | EPHX2 (0.68) | EPHX2 | |
| SCHEMBL15686029 | 0.80 | EPHX2 (0.60) | EPHX2 | |
| SCHEMBL15686054 | 0.80 | EPHX2 (0.60) | EPHX2 | |
| SCHEMBL15686069 | 0.79 | EPHX2 (0.66) | EPHX2 | |
| SCHEMBL23479957 | 0.78 | EPHX2 (0.81) | EPHX2 | |
| SCHEMBL15109208 | 0.78 | EPHX2 (0.81) | EPHX2 | |
| SCHEMBL15249710 | 0.78 | EPHX2 (0.81) | EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11358968-B2 | Substituted epoxyeicosatrienoic acid (EET) analogs for treatment of kidney disease | THE MEDICAL COLLEGE OF WISCONSIN, INC. (US) | 2022-06-14 | — | — | US | disclosed |
| US-11130772-B2 | CYP-eicosanoid derivatives | MAX-DELBRUECK-CENTRUM FUER MOLEKULARE MEDIZIN | 2021-09-28 | — | — | US | disclosed |
| EP-3097076-B1 | NOVEL CYP-EICOSANOID DERIVATIVES | MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN (DE) | 2019-05-08 | — | — | EP | disclosed |
| US-20170008918-A1 | NOVEL CYP-EICOSANOID DERIVATIVES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-01-12 | — | — | US | disclosed |
| US-9422318-B2 | Epoxyeicosatrienoic acid analogs and methods of making and using the same | THE MEDICAL COLLEGE OF WISCONSIN, INC. (US) | 2016-08-23 | — | — | US | disclosed |
| US-9422318-B2 | Epoxyeicosatrienoic acid analogs and methods of making and using the same | THE MEDICAL COLLEGE OF WISCONSIN, INC. (US) | 2016-08-23 | — | — | US | disclosed |
| EP-2694470-B1 | EPOXYEICOSATRIENOIC ACID ANALOGS AND METHODS OF MAKING AND USING THE SAME | WISCONSIN MED COLLEGE INC (US) | 2016-06-01 | — | — | EP | disclosed |
| US-20150336916-A1 | EPOXYEICOSATRIENOIC ACID ANALOGS AND METHODS OF MAKING AND USING THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-11-26 | — | — | US | disclosed |
| US-20150336916-A1 | EPOXYEICOSATRIENOIC ACID ANALOGS AND METHODS OF MAKING AND USING THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-11-26 | — | — | US | disclosed |
| US-9127027-B2 | Epoxyeicosatrienoic acid analogs and methods of making and using the same | THE MEDICAL COLLEGE OF WISCONSIN, INC. (US) | 2015-09-08 | — | — | US | disclosed |
| US-9127027-B2 | Epoxyeicosatrienoic acid analogs and methods of making and using the same | THE MEDICAL COLLEGE OF WISCONSIN, INC. (US) | 2015-09-08 | — | — | US | disclosed |
| WO-2015110262-A1 | NOVEL CYP-EICOSANOID DERIVATIVES | Max-Delbrück-Centrum für Molekulare Medizin (DE) | 2015-07-30 | — | — | WO | disclosed |
| US-20140113884-A1 | EPOXYEICOSATRIENOIC ACID ANALOGS AND METHODS OF MAKING AND USING THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-04-24 | — | — | US | disclosed |
| US-20140113884-A1 | EPOXYEICOSATRIENOIC ACID ANALOGS AND METHODS OF MAKING AND USING THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-04-24 | — | — | US | disclosed |
| WO-2012138706-A1 | EPOXYEICOSATRIENOIC ACID ANALOGS AND METHODS OF MAKING AND USING THE SAME | MCW RESEARCH FOUNDATION, INC. (US) | 2012-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170008918-A1 | NOVEL CYP-EICOSANOID DERIVATIVES | CYP4F3, ALOX5, CYP4A11 | EPHX2 76/4885 |
| US-20150336916-A1 | EPOXYEICOSATRIENOIC ACID ANALOGS AND METHODS OF MAKING AND USING THE SAME | PTGER1, PTGES, PTGER2 | EPHX2 24/4885 |
| US-11358968-B2 | Substituted epoxyeicosatrienoic acid (EET) analogs for treatment of kidney disease | FOLR1, FOLR2, SLC46A1 | EPHX2 25/4885 |
| US-20140113884-A1 | EPOXYEICOSATRIENOIC ACID ANALOGS AND METHODS OF MAKING AND USING THE SAME | PTGER1, PTGES, PTGER2 | EPHX2 24/4885 |
| US-11130772-B2 | CYP-eicosanoid derivatives | CYP4F3, CYP4A11, CYP1A2 | EPHX2 75/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.