SCHEMBL1319364

SCHEMBL1319364

O=C(Nc1cc(-c2ccccc2F)ccc1C(=O)O)c1cncc(-c2ccccc2)c1

nearest known ligand 0.52

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ACLY P53396 3/20 0.52
KAT6A Q92794 1/20 0.49
ALDH1A1 P00352 1/20 0.49
AXL P30530 1/20 0.48
DHODH Q02127 1/20 0.47
ABCB1 P08183 2/20 0.47
ACMSD Q8TDX5 1/20 0.46
CTSA P10619 1/20 0.46
HDAC1 Q13547 3/20 0.45
SCN10A Q9Y5Y9 1/20 0.45
SUCNR1 Q9BXA5 1/20 0.45
SERPINE1 P05121 1/20 0.45
HDAC3 O15379 1/20 0.44
HDAC2 Q92769 1/20 0.44
XDH P47989 1/20 0.43
CCNC P24863 1/20 0.43
CDK8 P49336 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1317189 0.99 ACLY (0.51) ACLYKAT6AALDH1A1AXLDHODH
SCHEMBL1319407 0.96 ACLY (0.55) ACLYKAT6AALDH1A1AXLDHODH
SCHEMBL1317188 0.91 KAT6A (0.47) ACLYKAT6AAXLABCB1CTSA
SCHEMBL1315751 0.89 ACLY (0.64) ACLYKAT6AALDH1A1DHODHHDAC1
SCHEMBL1316819 0.88 ACLY (0.51) ACLYALDH1A1DHODHHDAC1SUCNR1
SCHEMBL12118197 0.88 ACLY (0.53) ACLYKAT6AALDH1A1DHODHHDAC1
SCHEMBL12118092 0.87 ACLY (0.52) ACLYALDH1A1DHODHCTSAHDAC1
SCHEMBL1317026 0.87 ACLY (0.52) ACLYKAT6AALDH1A1DHODHHDAC1
SCHEMBL1316095 0.87 ACLY (0.52) ACLYKAT6AALDH1A1DHODHHDAC1
SCHEMBL1318831 0.86 KAT6A (0.46) ACLYKAT6AAXLABCB1CTSA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 US disclosed
EP-2385036-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF Toyama Chemical Co., Ltd. (JP) 2011-11-09 EP disclosed
WO-2010087430-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF 富山化学工業株式会社 (JP) 2010-08-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF COL14A1, COL2A1, COL1A1 ACLY 295/4885KAT6A 435/4885ALDH1A1 813/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.