Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.65 |
| ▸ | CNR2 | P34972 | 8/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
| ▸ | GAPDH | P04406 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KLK7 | P49862 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1257126 | 0.87 | ALDH1A1 (0.53) | MAPK14CNR2ALDH1A1GAPDHRAB9A | |
| SCHEMBL13200823 | 0.87 | CNR2 (0.53) | MAPK14CNR2ALDH1A1GAPDHRAB9A | |
| SCHEMBL13199944 | 0.85 | ALDH1A1 (0.51) | MAPK14CNR2ALDH1A1GAPDH | |
| SCHEMBL13200803 | 0.85 | KMT2A (0.61) | MAPK14CNR2ALDH1A1L3MBTL1KLK7 | |
| SCHEMBL13200489 | 0.83 | CNR2 (0.50) | MAPK14CNR2ALDH1A1GAPDH | |
| SCHEMBL15529021 | 0.83 | ALDH1A1 (0.62) | CNR2ALDH1A1GAPDHRAB9ANPC1 | |
| SCHEMBL1256126 | 0.80 | ALDH1A1 (0.46) | MAPK14CNR2ALDH1A1GAPDH | |
| SCHEMBL13234510 | 0.80 | MAPK14 (0.56) | MAPK14ALDH1A1 | |
| SCHEMBL1257251 | 0.80 | ALDH1A1 (0.48) | MAPK14CNR2ALDH1A1GAPDHRAB9A | |
| SCHEMBL13200487 | 0.79 | ALDH1A1 (0.45) | MAPK14CNR2ALDH1A1GAPDHRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |