Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | RAF1 | P04049 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.47 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KLK7 | P49862 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13200489 | 0.88 | CNR2 (0.50) | KMT2AKDM4EALDH1A1RAF1CNR2 | |
| SCHEMBL1257126 | 0.85 | ALDH1A1 (0.53) | KMT2AALDH1A1RAF1HTTSMN1; SMN2 | |
| SCHEMBL13200823 | 0.85 | CNR2 (0.53) | KDM4EALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL13199941 | 0.85 | MAPK14 (0.65) | ALDH1A1L3MBTL1CNR2KLK7MAPK14 | |
| SCHEMBL2961183 | 0.84 | MAPK14 (0.47) | KMT2AKDM4EALDH1A1HPGDRAF1 | |
| SCHEMBL13200487 | 0.84 | ALDH1A1 (0.45) | KMT2AKDM4EALDH1A1RAF1SMN1; SMN2 | |
| SCHEMBL13234462 | 0.83 | ALDH1A1 (0.55) | KMT2AKDM4EALDH1A1RAF1HTT | |
| SCHEMBL13199944 | 0.83 | ALDH1A1 (0.51) | KMT2AALDH1A1RAF1SMN1; SMN2CNR2 | |
| SCHEMBL13234433 | 0.80 | RAF1 (0.74) | KMT2AALDH1A1RAF1SMN1; SMN2MEN1 | |
| SCHEMBL13199934 | 0.79 | KDM4E (0.71) | KMT2AKDM4EALDH1A1HPGDRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |