Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | GAPDH | P04406 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13199941 | 0.87 | MAPK14 (0.65) | CNR2ALDH1A1MAPK14NPC1RAB9A | |
| SCHEMBL1257126 | 0.87 | ALDH1A1 (0.53) | CNR2ALDH1A1MAPK14SMN1; SMN2NPC1 | |
| SCHEMBL13200803 | 0.85 | KMT2A (0.61) | CNR2ALDH1A1MAPK14SMN1; SMN2KDM4E | |
| SCHEMBL13199944 | 0.85 | ALDH1A1 (0.51) | CNR2ALDH1A1MAPK14SMN1; SMN2GAPDH | |
| SCHEMBL13200489 | 0.83 | CNR2 (0.50) | CNR2ALDH1A1MAPK14GAPDHKDM4E | |
| SCHEMBL1257251 | 0.82 | ALDH1A1 (0.48) | CNR2ALDH1A1MAPK14SMN1; SMN2NPC1 | |
| SCHEMBL1257388 | 0.81 | RET (0.43) | CNR2ALDH1A1MAPK14GAPDH | |
| SCHEMBL1256126 | 0.80 | ALDH1A1 (0.46) | CNR2ALDH1A1MAPK14GAPDH | |
| SCHEMBL1256097 | 0.80 | MAPK14 (0.43) | CNR2ALDH1A1MAPK14 | |
| SCHEMBL1621220 | 0.80 | ALDH1A1 (0.48) | CNR2ALDH1A1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |