Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 3/20 | 0.48 |
| ▸ | RET | P07949 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.42 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.42 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13234883 | 0.83 | MAPK14 (0.62) | FLT3MEN1NPC1RAB9AKMT2A | |
| SCHEMBL13199940 | 0.79 | FLT3 (0.65) | FLT3MEN1NPC1RAB9AKMT2A | |
| SCHEMBL13199938 | 0.78 | FLT3 (0.55) | FLT3MEN1NPC1RAB9AKMT2A | |
| SCHEMBL13200568 | 0.78 | FLT3 (0.53) | FLT3RETMEN1NPC1RAB9A | |
| SCHEMBL13200317 | 0.77 | RET (0.58) | FLT3RETKDRNTRK1EGFR | |
| SCHEMBL13199947 | 0.76 | FLT3 (0.53) | FLT3MEN1NPC1RAB9AKMT2A | |
| SCHEMBL13200000 | 0.74 | MAPT (0.53) | FLT3MEN1NPC1RAB9AKMT2A | |
| SCHEMBL13234900 | 0.74 | MAPK14 (0.61) | FLT3MEN1NPC1RAB9AKMT2A | |
| SCHEMBL13200599 | 0.73 | FLT3 (0.57) | FLT3MEN1NPC1RAB9AKMT2A | |
| SCHEMBL13200526 | 0.73 | RAF1 (0.67) | FLT3MEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |