Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13234593 | 0.85 | RAF1 (0.64) | MAPK14NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL13200803 | 0.84 | KMT2A (0.61) | MAPK14CNR2SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL13200487 | 0.83 | ALDH1A1 (0.45) | MAPK14CNR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13200489 | 0.82 | CNR2 (0.50) | MAPK14CNR2ALDH1A1NR1H4RAF1 | |
| SCHEMBL13200553 | 0.82 | RAB9A (0.57) | MAPK14NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL13200476 | 0.82 | FLT3 (0.65) | MAPK14NPC1RAB9ARAF1FLT3 | |
| SCHEMBL1257126 | 0.79 | ALDH1A1 (0.53) | MAPK14CNR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13200823 | 0.79 | CNR2 (0.53) | MAPK14CNR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13199941 | 0.79 | MAPK14 (0.65) | MAPK14CNR2NPC1RAB9AALDH1A1 | |
| SCHEMBL13200504 | 0.79 | MAPK14 (0.70) | MAPK14KMT2AMEN1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-20050261315-A1 | Amide derivatives as kinase modulators | AMBIT BIOSCIENCES CORPORATION | 2005-11-24 | — | — | US | disclosed |
| US-20050171171-A1 | Amide derivatives as FLT-3 modulators | AMBIT BIOSCIENCES CORPORATION | 2005-08-04 | — | — | US | disclosed |
| US-20050171172-A1 | Amide derivatives as PDGFR modulators | AMBIT BIOSCIENCES CORPORATION | 2005-08-04 | — | — | US | disclosed |
| US-20050165074-A1 | Amide derivatives as C-KIT modulators | AMBIT BIOSCIENCES CORPORATION | 2005-07-28 | — | — | US | disclosed |
| US-20050148605-A1 | Amide derivatives as ABL modulators | AMBIT BIOSCIENCES CORPORATION | 2005-07-07 | — | — | US | disclosed |
| WO-2005048953-A2 | AMIDE DERIVATIVES AS KINASE MODULATORS | AMBIT BIOSCIENCES CORPORATION (US) | 2005-06-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261315-A1 | Amide derivatives as kinase modulators | MAP3K20, MAP3K1, MAP3K2 | MAPK14 262/4885RORC 1170/4885CNR2 832/4885 |
| US-20050171171-A1 | Amide derivatives as FLT-3 modulators | FLT4, FLT1, FLT3 | MAPK14 1721/4885RORC 1354/4885CNR2 2702/4885 |
| US-20050165074-A1 | Amide derivatives as C-KIT modulators | KIT, PRKCH, PRKCE | MAPK14 1295/4885RORC 1334/4885CNR2 1183/4885 |
| US-20050171172-A1 | Amide derivatives as PDGFR modulators | PDGFRA, PDGFRB, PDGFA | MAPK14 1991/4885RORC 1225/4885CNR2 234/4885 |
| US-20050148605-A1 | Amide derivatives as ABL modulators | ABL2, ABL1, PDGFRA | MAPK14 920/4885RORC 743/4885CNR2 977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.