Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.56 |
| ▸ | DUSP3 | P51452 | 3/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.55 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.55 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.55 |
| ▸ | CSNK1D | P48730 | 5/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.52 |
| ▸ | SCD | O00767 | 1/20 | 0.52 |
| ▸ | MET | P08581 | 1/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.51 |
| ▸ | ACP1 | P24666 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13234642 | 0.87 | POLB (0.61) | POLBGAAL3MBTL1DYRK1ADUSP3 | |
| SCHEMBL20671497 | 0.82 | DUSP3 (0.62) | POLBGAAL3MBTL1DYRK1ADUSP3 | |
| SCHEMBL13200871 | 0.82 | CSNK1D (0.77) | POLBGAADYRK1ACSNK1DNFKB1 | |
| SCHEMBL1042240 | 0.80 | DYRK1A (0.65) | POLBGAAL3MBTL1DYRK1ADUSP3 | |
| SCHEMBL9333376 | 0.77 | DYRK1A (0.74) | POLBGAAL3MBTL1DYRK1ADUSP3 | |
| SCHEMBL13200869 | 0.77 | WNT3A (0.64) | DYRK1ACSNK1DNFKB1NFKB2RELA | |
| SCHEMBL3052053 | 0.77 | DYRK1A (0.66) | POLBGAAL3MBTL1DYRK1ADUSP3 | |
| SCHEMBL8350097 | 0.76 | DYRK1A (0.72) | POLBGAAL3MBTL1DYRK1ADUSP3 | |
| SCHEMBL7931743 | 0.76 | DYRK1A (0.72) | POLBGAAL3MBTL1DYRK1ADUSP3 | |
| SCHEMBL20660046 | 0.76 | DYRK1A (0.80) | POLBGAAL3MBTL1DYRK1ADUSP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |